Tabla general – Apertura 2021
| Pos | Equipo | Pts | P | G | E | D | GF | GC | DIF |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Club América | 31 | 14 | 9 | 4 | 1 | 19 | 8 | 11 |
| 2 |  Atlas | 23 | 14 | 6 | 5 | 3 | 13 | 6 | 7 |
| 3 |  Tigres | 22 | 14 | 5 | 7 | 2 | 21 | 12 | 9 |
| 4 |  Toluca | 22 | 14 | 6 | 4 | 4 | 20 | 19 | 1 |
| 5 |  Monterrey | 20 | 14 | 5 | 5 | 4 | 18 | 14 | 4 |
| 6 |  Mazatlan FC | 20 | 15 | 5 | 5 | 5 | 17 | 21 | -4 |
| 7 |  Cruz Azul | 19 | 13 | 4 | 7 | 2 | 15 | 10 | 5 |
| 8 |  León | 19 | 13 | 5 | 4 | 4 | 15 | 14 | 1 |
| 9 |  Chivas | 18 | 14 | 4 | 6 | 4 | 10 | 10 | 0 |
| 10 |  Puebla | 18 | 14 | 4 | 6 | 4 | 13 | 15 | -2 |
| 11 |  A. San Luis | 17 | 13 | 4 | 5 | 4 | 16 | 16 | 0 |
| 12 |  Santos | 16 | 13 | 3 | 7 | 3 | 15 | 12 | 3 |
| 13 |  Pachuca | 15 | 13 | 4 | 3 | 6 | 15 | 16 | -1 |
| 14 |  Querétaro | 15 | 15 | 3 | 6 | 6 | 9 | 14 | -5 |
| 15 |  Juárez | 15 | 14 | 4 | 3 | 7 | 13 | 19 | -6 |
| 16 |  Necaxa | 14 | 14 | 4 | 2 | 8 | 13 | 18 | -5 |
| 17 |  Pumas | 14 | 13 | 3 | 5 | 5 | 9 | 15 | -6 |
| 18 |  Xolos | 9 | 14 | 1 | 6 | 7 | 10 | 22 | -12 |
