Tabla general – Guardianes 2021
| Pos | Equipo | Pts | P | G | E | D | GF | GC | DIF |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Cruz Azul | 41 | 17 | 13 | 2 | 2 | 26 | 11 | 15 |
| 2 |  Club América | 38 | 17 | 12 | 2 | 3 | 26 | 14 | 12 |
| 3 |  Puebla | 28 | 17 | 7 | 7 | 3 | 25 | 14 | 11 |
| 4 |  Monterrey | 28 | 17 | 8 | 4 | 5 | 22 | 13 | 9 |
| 5 |  Santos | 26 | 17 | 7 | 5 | 5 | 18 | 13 | 5 |
| 6 |  León | 26 | 17 | 8 | 2 | 7 | 25 | 23 | 2 |
| 7 |  Atlas | 25 | 17 | 7 | 4 | 6 | 20 | 15 | 5 |
| 8 |  Pachuca | 23 | 17 | 6 | 5 | 6 | 20 | 19 | 1 |
| 9 |  Chivas | 23 | 17 | 5 | 8 | 4 | 21 | 21 | 0 |
| 10 |  Tigres | 23 | 17 | 6 | 5 | 6 | 19 | 20 | -1 |
| 11 |  Toluca | 22 | 17 | 6 | 4 | 7 | 26 | 24 | 2 |
| 12 |  Querétaro | 21 | 17 | 6 | 3 | 8 | 19 | 25 | -6 |
| 13 |  Mazatlan FC | 21 | 17 | 6 | 3 | 8 | 19 | 26 | -7 |
| 14 |  Xolos | 20 | 17 | 5 | 5 | 7 | 19 | 21 | -2 |
| 15 |  Pumas | 18 | 17 | 4 | 6 | 7 | 10 | 12 | -2 |
| 16 |  Juárez | 15 | 17 | 4 | 3 | 10 | 13 | 29 | -16 |
| 17 |  A. San Luis | 12 | 17 | 3 | 3 | 11 | 20 | 33 | -13 |
| 18 |  Necaxa | 11 | 17 | 2 | 5 | 10 | 14 | 29 | -15 |
