Tabla general – Guardianes 2021
| Pos | Equipo | Pts | P | G | E | D | GF | GC | DIF |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Cruz Azul | 21 | 9 | 7 | 0 | 2 | 14 | 5 | 9 |
| 2 |  Club América | 19 | 9 | 6 | 1 | 2 | 12 | 7 | 5 |
| 3 |  Toluca | 17 | 9 | 5 | 2 | 2 | 16 | 9 | 7 |
| 4 |  Monterrey | 15 | 8 | 4 | 3 | 1 | 12 | 4 | 8 |
| 5 |  Puebla | 15 | 9 | 4 | 3 | 2 | 10 | 5 | 5 |
| 6 |  Santos | 15 | 9 | 4 | 3 | 2 | 9 | 6 | 3 |
| 7 |  Xolos | 13 | 9 | 3 | 4 | 2 | 11 | 10 | 1 |
| 8 |  Atlas | 12 | 9 | 3 | 3 | 3 | 8 | 7 | 1 |
| 9 |  A. San Luis | 11 | 9 | 3 | 2 | 4 | 14 | 14 | 0 |
| 10 |  Tigres | 11 | 8 | 3 | 2 | 3 | 10 | 10 | 0 |
| 11 |  Chivas | 11 | 9 | 2 | 5 | 2 | 14 | 14 | 0 |
| 12 |  Querétaro | 11 | 9 | 3 | 2 | 4 | 12 | 16 | -4 |
| 13 |  Mazatlan FC | 10 | 9 | 3 | 1 | 5 | 8 | 14 | -6 |
| 14 |  Pumas | 8 | 9 | 2 | 2 | 5 | 5 | 7 | -2 |
| 15 |  Juárez | 8 | 8 | 2 | 2 | 4 | 7 | 17 | -10 |
| 16 |  León | 7 | 8 | 2 | 1 | 5 | 6 | 11 | -5 |
| 17 |  Necaxa | 7 | 9 | 1 | 4 | 4 | 9 | 14 | -5 |
| 18 |  Pachuca | 4 | 9 | 0 | 4 | 5 | 5 | 12 | -7 |
